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Results for "

microtubule protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Microtubule/Tubulin (17) ADC Cytotoxin (1) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (2) Apoptosis (8) Caspase (1) Drug-Linker Conjugates for ADC (2) HDAC (1) Kinesin (2) PARP (1) Tau Protein (3)
By Research Areas:	Cancer (21) Endocrinology (2) Inflammation/Immunology (3) Neurological Disease (5)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Microtubule/Tubulin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16062

ARQ 621	Kinesin	Cancer
ARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity . ARQ 621 is a kinesin inhibitor . ARQ 621 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-144425

BSc5367	Others	Inflammation/Immunology
BSc5367 is a potent Nek1 inhibitor with an IC₅₀ of 11.5 nM. NIMA-related protein kinase Nek1 is crucially involved in cell cycle regulation, DNA repair and microtubule regulation and dysfunctions of Nek1 play key roles in amyotrophic lateral sclerosis (ALS), polycystic kidney disease (PKD) and several types of radiotherapy resistant cancer .

HY-P0181

Microtubule-associated protein tau (26-44)	Tau Protein	Neurological Disease
Microtubule-associated protein tau (26-44) is a synthetic peptide chain with an amine group attached to glutamine and an carboxyl group attached to lysine.

HY-P4808

PHF6	Amyloid-β	Neurological Disease
PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein .

HY-147317

Epothilone E	Microtubule/Tubulin	Cancer
Epothilone E is a related compound of epothilone, which inhibits microtubule protein function and blocks cell division, and has anti-tumor activity .

HY-13442

Eribulin 1 Publications Verification B1939; E7389; ER-086526	Microtubule/Tubulin Apoptosis ADC Cytotoxin	Cancer
Eribulin (E7389) is a *microtubule* targeting agent that is used for the research of metastatic breast cancer. Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

HY-13442A

Eribulin mesylate 1 Publications Verification B1939 mesylate; E7389 mesylate; ER-086526 mesylate	Microtubule/Tubulin Apoptosis	Cancer
Eribulin (E7389) mesylate is a *microtubule* targeting agent that is used for the research of metastatic breast cancer. Eribulin mesylate inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

HY-U00004

OSIP-486823 OSIP 486823; OSIP486823; CP248	Microtubule/Tubulin	Cancer
OSIP-486823 is a novel *microtubule*-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules.

HY-15857

CW-069

1 Publications Verification

Kinesin Cancer

CW-069 is an allosteric inhibitor of microtubule motor protein HSET with an IC₅₀ of 75 μM.
HY-P9995

Posdinemab

JNJ-63733657
Tau Protein Cancer

Posdinemab is a humanized IgG1κ antibody, targeting to microtubule-associated protein tau (MAPT) .

CW-069 1 Publications Verification	Kinesin	Cancer
CW-069 is an allosteric inhibitor of microtubule motor protein HSET with an IC₅₀ of 75 μM.

Posdinemab JNJ-63733657	Tau Protein	Cancer
Posdinemab is a humanized IgG1κ antibody, targeting to microtubule-associated protein tau (MAPT) .

HY-162086A

HDAC-IN-69	HDAC	Cancer
HDAC-IN-69 (Compound 29) has inhibitory activity against HDACs (IC₅₀=0.04 μM) and fragments microtubules by activating katanin, a microtubule-severing protein. HDAC-IN-69 can be used in cancer research .

HY-128870

Mal-PEG2-VCP-Eribulin	Drug-Linker Conjugates for ADC	Cancer
Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin (HY-13442). Eribulin is a mechanistically unique microtubule inhibitor and Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Mal-PEG2-VCP-Eribulin is an Eribulin-based agent for antibody conjugates .

HY-13627

Estramustine phosphate sodium	Microtubule/Tubulin Apoptosis	Inflammation/Immunology Endocrinology Cancer
Estramustine phosphate sodium, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate sodium depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate sodium can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer .

HY-13627A

Estramustine phosphate	Apoptosis Microtubule/Tubulin	Inflammation/Immunology Endocrinology Cancer
Estramustine phosphate, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer .

HY-N3225

Myricanol	Others	Others
Myricanol is a constituent of Myrica cerifera (bayberry/southern wax myrtle) root bark. Myricanol can lower the levels of the microtubule-associated protein tau (MAPT) .

HY-111548

Spastazoline 2 Publications Verification	Others	Others
Spastazoline is a selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC₅₀ of 99 nM for Human spastin. Spastazoline can be used for cell division- and intracellular vesicle transport-related research .

HY-128902

MC-Val-Cit-PAB-vinblastine	Drug-Linker Conjugates for ADC	Cancer
MC-Val-Cit-PAB-vinblastine is a agent-linker conjugate for ADC with potent antitumor activity by using vinblastine (an microtubule protein inhibitor), linked via the ADC linker MC-Val-Cit-PAB.

HY-P2516

Tau Peptide (275-305) (Repeat 2 domain)	Tau Protein	Neurological Disease
Tau Peptide (275-305) (Repeat 2 domain) is the Alzheimer's tau fragment R2, corresponding to the second repeat unit of the microtubule-binding domain, which is believed to be pivotal to the biochemical properties of full tau protein .

HY-107116

MAP4343	Microtubule/Tubulin	Neurological Disease
MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents .

HY-111752

EML4-ALK kinase inhibitor 1	Anaplastic lymphoma kinase (ALK)	Cancer
EML4-ALK kinase inhibitor 1 is a potent orally active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC₅₀ of 1 nM .

HY-112140

JH-VIII-157-02	Anaplastic lymphoma kinase (ALK)	Cancer
JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC₅₀ of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells.

HY-149918

Antiproliferative agent-23	Microtubule/Tubulin Apoptosis	Cancer
Antiproliferative agent-23 is a microtubule-destabilizing agent (MDA) and efficiently disturbes the tubulin-microtubule system. Antiproliferative agent-23 induces apoptosis via a mitochondrion-dependent pathway by downregulating the Bcl-2 protein, upregulating Bax and Cyt c proteins, and activating the caspase cascade. Antiproliferative agent-23 initiates reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells (cisplatin resistant cancer cell line) via the PERK/ATF4/CHOP signaling pathway. Antiproliferative agent-23 has anti-tumor activity .

HY-P3894

P34cdc2 Kinase Fragment	Microtubule/Tubulin	Others
P34cdc2 Kinase Fragment is associated with the completion of DNA replication in yeast mitosis. P34cdc2 Kinase can phosphorylate mitogen-activated protein 2 (MAP2) to regulate microtubules polymerization in Xenopus oocytes meiosis .

HY-146778

Tubulin inhibitor 25	Microtubule/Tubulin	Cancer
Tubulin inhibitor 25 is a potent tubulin inhibitor with an IC₅₀ value of 0.98 μM. Tubulin inhibitor 25 exhibits remarkable activity against cancer cell line HT29. Tubulin inhibitor 25 displays the potent inhibition on cell migration and tube formation that contributes to the anti-angiogenesis .

HY-157800

Trilexium TRX-E-009-1	Microtubule/Tubulin Apoptosis PARP Caspase	Cancer
Trilexium (TRX-E-009-1) is a third-generation of benzopyran structurally related to TRX-E-002-1 (HY-114250). Trilexium increases p21 protein expression and induces apoptosis. Trilexium depolymerizes *microtubules*. Trilexium shows broad anti-cancer activity .

HY-N3028

Taccalonolide B	Microtubule/Tubulin	Cancer
Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC₅₀ of 208 nM .

HY-107116S

MAP4343-d4	Microtubule/Tubulin
MAP4343-d₄ is the deuterium labeled MAP4343. MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents[1][2][3].

HY-163105

Tubulin/NEDDylation-IN-1	Microtubule/Tubulin	Cancer
Tubulin/NEDDylation-IN-1 (compound C11) is a dual inhibitor of tubulin (Microtubule/Tubulin)-NEDDylation (IC₅₀ for tubulin=2.40 μM), which has strong anti-proliferative activity. Neddylation is a protein post-translational modification that covalently tags the ubiquitin-like protein NEDD8 to target proteins. Tubulin/NEDDylation-IN-1 forms hydrogen bonds with residues of tubulin and E1 NEDD8 activating enzyme (NAE) through methoxy and dithiocarbamate groups and inhibits NEDDylation and microtubulin in an ATP-dependent manner. tube polymerization .

HY-149021

Tubulin polymerization-IN-28	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-28 (compound-4) is a microtubule protein polymerization inhibitor with highly selective anticancer activity. Tubulin polymerization-IN-28 can be activated by NQO1 and effectively release combretastatin A-4 to kill tumor cells. Tubulin polymerization-IN-28 can induce cell apoptosis and be used in anti-cancer research .

HY-N2416

Taccalonolide A	Microtubule/Tubulin Apoptosis	Cancer
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities . Taccalonolide A causes G₂-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis . Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC₅₀ of 622 nM for SK-OV-3 cells .

HY-105066

Davunetide	Microtubule/Tubulin Amyloid-β	Neurological Disease
Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a *microtubule-stabilizing* peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity .

Cat. No.	Product Name

HY-L060

Cytoskeleton Compound Library	1254 compounds
The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases. MCE designs a unique collection of 1254 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cytoskeleton Compound Library

1254 compounds

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases.

MCE designs a unique collection of 1254 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

HY-L075

Anti-Lung Cancer Compound Library	1835 compounds
Lung cancer is a major global health problem, as it is the leading cause of cancer-related deaths worldwide. Lung cancer is divided into two categories: small cell lung cancer and non-small cell lung cancer (NSCLC). Non-small cell lung cancer accounts for about 85 percent of lung cancers. As with all cancers, lung cancer may be treated with surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. Targeted therapy is one of the most exciting developments in lung cancer medicine, especially for NSCLC. Extensive genomic characterization of NSCLC has led to the identification of molecular subtypes of NSCLC that are oncogene addicted and exquisitely sensitive to targeted therapies. These include activating mutations in epidermal growth factor receptor (EGFR) and BRAF or echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusions and ROS1 receptor tyrosine kinase fusions. These are important targets for target therapy. MCE offers a unique collection of 1835 compounds with identified and potential anti-lung cancer activity. These compounds target lung cancer’s major targets and signaling pathways. MCE anti-lung cancer compound library is a useful tool for anti-lung cancer drugs screening and other related research.

Anti-Lung Cancer Compound Library

1835 compounds

Lung cancer is a major global health problem, as it is the leading cause of cancer-related deaths worldwide. Lung cancer is divided into two categories: small cell lung cancer and non-small cell lung cancer (NSCLC). Non-small cell lung cancer accounts for about 85 percent of lung cancers.

As with all cancers, lung cancer may be treated with surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. Targeted therapy is one of the most exciting developments in lung cancer medicine, especially for NSCLC. Extensive genomic characterization of NSCLC has led to the identification of molecular subtypes of NSCLC that are oncogene addicted and exquisitely sensitive to targeted therapies. These include activating mutations in epidermal growth factor receptor (EGFR) and BRAF or echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusions and ROS1 receptor tyrosine kinase fusions. These are important targets for target therapy.

MCE offers a unique collection of 1835 compounds with identified and potential anti-lung cancer activity. These compounds target lung cancer’s major targets and signaling pathways. MCE anti-lung cancer compound library is a useful tool for anti-lung cancer drugs screening and other related research.

Cat. No.	Product Name	Target	Research Area

HY-P0181

Microtubule-associated protein tau (26-44)	Tau Protein	Neurological Disease
Microtubule-associated protein tau (26-44) is a synthetic peptide chain with an amine group attached to glutamine and an carboxyl group attached to lysine.

HY-P4754

Microtubule-Associated Protein (142-161) (human)	Peptides	Others
Microtubule-Associated Protein (142-161) (human) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4808

PHF6	Amyloid-β	Neurological Disease
PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein .

HY-P2516

Tau Peptide (275-305) (Repeat 2 domain)	Tau Protein	Neurological Disease
Tau Peptide (275-305) (Repeat 2 domain) is the Alzheimer's tau fragment R2, corresponding to the second repeat unit of the microtubule-binding domain, which is believed to be pivotal to the biochemical properties of full tau protein .

HY-P3894

P34cdc2 Kinase Fragment	Microtubule/Tubulin	Others
P34cdc2 Kinase Fragment is associated with the completion of DNA replication in yeast mitosis. P34cdc2 Kinase can phosphorylate mitogen-activated protein 2 (MAP2) to regulate microtubules polymerization in Xenopus oocytes meiosis .

HY-105066

Davunetide	Microtubule/Tubulin Amyloid-β	Neurological Disease
Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a *microtubule-stabilizing* peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity .

Posdinemab JNJ-63733657	Tau Protein	Cancer
Posdinemab is a humanized IgG1κ antibody, targeting to microtubule-associated protein tau (MAPT) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3225

Myricanol	Myrica ceriferaL. Source classification Phenols Polyphenols Plants Myricaceae	Others
Myricanol is a constituent of Myrica cerifera (bayberry/southern wax myrtle) root bark. Myricanol can lower the levels of the microtubule-associated protein tau (MAPT) .

HY-N3028

Taccalonolide B	Structural Classification Classification of Application Fields Source classification Schizocapsa plantaginea Hance Plants Disease Research Fields Taccaceae Steroids Cancer	Microtubule/Tubulin
Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC₅₀ of 208 nM .

HY-N2416

Taccalonolide A	Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Tacca chantrieri Andre Taccaceae Steroids Cancer	Microtubule/Tubulin Apoptosis
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities . Taccalonolide A causes G₂-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis . Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC₅₀ of 622 nM for SK-OV-3 cells .

Species:	Human (12) Rhesus Macaque (1) Mouse (3) Rat (2)
Tag:	His (13) Tag Free (4) GST (1)
Source:	HEK293 (4) P. pastoris (2) E. coli (12)

Cat. No.	Compare	Product Name	Species	Source

HY-P71752

	Microtubule-associated protein tau Protein, Mouse (P.pastoris, His) Mapt; Mtapt; Tau; microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau	Mouse	P. pastoris
	Microtubule-associated protein tau (MAPT) plays a key role in promoting microtubule assembly and stability, suggesting its potential contribution to the establishment of neuronal polarity. The C terminus binds to axonal microtubules, whereas the N terminus interacts with neuroplasmic membrane components, serving as a key linker protein between these structures. Microtubule-associated protein tau Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Microtubule-associated protein tau protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Microtubule-associated protein tau Protein, Mouse (P.pastoris, His) is 732 a.a., with molecular weight of ~78.1 kDa.

HY-P71753

	Microtubule-associated protein tau Protein, Rat (P.pastoris, His) Mapt; Mtapt; Tau; microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau	Rat	P. pastoris
	Microtubule-associated protein tau (MAPT) critically promotes microtubule assembly and stability, influencing neuronal polarity by acting as an important junction protein. Its dual role involves C-terminal binding to axonal microtubules and N-terminal binding to neuroplasmic membrane components. Microtubule-associated protein tau Protein, Rat (P.pastoris, His) is the recombinant rat-derived Microtubule-associated protein tau protein, expressed by P. pastoris , with N-His labeled tag. The total length of Microtubule-associated protein tau Protein, Rat (P.pastoris, His) is 751 a.a., with molecular weight of ~80.4 kDa.

HY-P701808

	MARK4 Protein, Human MARK4; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase-like 1	Human	E. coli
	MARK4 is a key serine/threonine protein kinase with crucial effects on cellular processes. It phosphorylates microtubule-associated proteins (MAPT/TAU, MAP2, MAP4) and reorganizes the microtubule network. MARK4 Protein, Human is the recombinant human-derived MARK4 protein, expressed by E. coli , with tag free. The total length of MARK4 Protein, Human is 327 a.a., .

HY-P701809

	MARK4 Protein, Human (His) MARK4; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase-like 1	Human	E. coli
	MARK4 is a key serine/threonine protein kinase with crucial effects on cellular processes. It phosphorylates microtubule-associated proteins (MAPT/TAU, MAP2, MAP4) and reorganizes the microtubule network. MARK4 Protein, Human (His) is the recombinant human-derived MARK4 protein, expressed by E. coli , with N-6*His labeled tag. The total length of MARK4 Protein, Human (His) is 327 a.a., .

HY-P700422

	Tau/MAPT Protein, Mouse (HEK293, His) MAPT; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; microtubule-associated protein tau; microtubule-associated protein tau; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; G protein beta1/gamma2 subunit-interacting factor 1	Mouse	HEK293
	Microtubule-associated protein tau (MAPT) plays a pivotal role in promoting microtubule assembly and stability, indicating its potential contribution to neuronal polarity establishment. The C-terminus binds to axonal microtubules, while the N-terminus interacts with neural plasma membrane components, serving as a crucial linker protein between these structures. Tau's localization within the neuronal cell, particularly in the centrosome-defined domain, dictates axonal polarity. Short MAPT isoforms enhance cytoskeletal plasticity, while longer isoforms stabilize it. MAPT engages in diverse interactions with proteins like MARK1, MARK2, MARK3, MARK4, SQSTM1, PSMC2, FKBP4, CSNK1D, SGK1, EPM2A, PIN1, LRRK2, and LRP1, participating in processes from ubiquitination to dephosphorylation and endocytosis, underscoring its multifaceted role in cellular dynamics. Tau/MAPT Protein, Mouse (HEK293, His) is the recombinant mouse-derived Tau/MAPT protein, expressed by HEK293, with N-10*His labeled tag. The total length of Tau/MAPT Protein, Mouse (HEK293, His) is 732 a.a., with molecular weight of 78.9 kDa.

HY-P700424

	Tau/MAPT Protein, Rat (HEK293, His) MAPT; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; microtubule-associated protein tau; microtubule-associated protein tau; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; G protein beta1/gamma2 subunit-interacting factor 1	Rat	HEK293
	Microtubule-associated protein tau (MAPT) critically promotes microtubule assembly and stability, influencing neuronal polarity by acting as a vital linker protein. Its dual role involves the C-terminus binding axonal microtubules and the N-terminus engaging neural plasma membrane components. Tau's cellular localization, especially near the centrosome, determines axonal polarity. Short tau isoforms offer cytoskeletal plasticity, while longer isoforms likely stabilize microtubules. MAPT engages with various proteins, including MARK1, MARK2, SQSTM1, LRP1, showcasing its multifaceted role in cellular processes. The interaction with LRP1, leading to endocytosis, highlights the intricate regulatory mechanisms governing tau's functional versatility. Tau/MAPT Protein, Rat (HEK293, His) is the recombinant rat-derived Tau/MAPT protein, expressed by HEK293, with N-10*His labeled tag. The total length of Tau/MAPT Protein, Rat (HEK293, His) is 751 a.a., with molecular weight of 81.2 kDa.

HY-P700421

	Tau-F/MAPT Protein, Human (HEK293, His) MAPT; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; microtubule-associated protein tau; microtubule-associated protein tau; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; G protein beta1/gamma2 subunit-interacting factor 1	Human	HEK293
	Microtubule-associated protein tau is a microtubule-associated protein found in large numbers in neurons of the central nervous system (CNS). MAPT promotes microtubule assembly and stability and may be involved in the establishment and maintenance of neuronal polarity. Overexpression of MAPT is associated with a poor prognosis of prostate cancer. MAPT has been linked to neurological disorders such as Alzheimer's and Parkinson's disease. Tau-F/MAPT Protein, Human (HEK293, His) is the recombinant human-derived Tau-F/MAPT protein, expressed by HEK293 , with N-10*His labeled tag. The total length of Tau-F/MAPT Protein, Human (HEK293, His) is 441 a.a., with molecular weight of 49.5 kDa.

HY-P700423

	Tau/MAPT Protein, Macaca mulatta (HEK293, His) MAPT; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; microtubule-associated protein tau; microtubule-associated protein tau; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; G protein beta1/gamma2 subunit-interacting factor 1	Rhesus Macaque	HEK293
	Tau/MAPT Protein crucially promotes microtubule assembly and stability, essential for neuronal polarity. Structurally, its C-terminus binds axonal microtubules, and the N-terminus engages neural plasma membrane components, suggesting a role as a linker protein connecting microtubules to the plasma membrane. Tau's localization dictates axonal polarity, particularly near the centrosome. Short isoforms offer cytoskeletal plasticity, while longer isoforms stabilize microtubules. Tau interacts with proteins like MARK1, MARK2, SQSTM1, and LRP1, revealing its multifaceted role in cellular processes. Tau/MAPT Protein, Macaca mulatta (HEK293, His) is the recombinant Rhesus Macaque-derived Tau/MAPT protein, expressed by HEK293, with N-10*His labeled tag. The total length of Tau/MAPT Protein, Macaca mulatta (HEK293, His) is 458 a.a., with molecular weight of 50.6 kDa.

HY-P74880

	HN1 Protein, Mouse (His) Jupiter microtubule associated homolog 1; Jpt1; Hn1	Mouse	E. coli
	HN1 protein negatively regulates AKT-mediated GSK3B signaling and induces the phosphorylation and degradation of CTNNB1 at “Ser-33”. This effect inhibits the “Ser-9” phosphorylation of GSK3B, inhibits the activity of APC:CTNNB1:GSK3B complex and blocks its interaction with CDH1. HN1 Protein, Mouse (His) is the recombinant mouse-derived HN1 protein, expressed by E. coli , with N-His labeled tag. The total length of HN1 Protein, Mouse (His) is 154 a.a., with molecular weight of ~18.3 kDa.

HY-P73618

	Tau/0N3R Protein, Human (351a.a, His) MAPT; Mtapt; Tau; microtubule-associated protein tau; PHF-tau	Human	E. coli
	Tau/0N3R protein is encoded by the Tau/0N3R gene and undergoes regulated alternative splicing to produce different mRNA species. Its expression varies in the nervous system according to the maturation and type of neurons. Tau/0N3R Protein, Human (351a.a, His) is the recombinant human-derived Tau/0N3R protein, expressed by E. coli , with N-His labeled tag. The total length of Tau/0N3R Protein, Human (351a.a, His) is 351 a.a., with molecular weight of 40-50 kDa.

HY-P75275

	EB3/MAPRE3 Protein, Human (His) microtubule-associated protein RP/EB family member 3; EBF3; EB3; RP3; MAPRE3	Human	E. coli
	The EB3/MAPRE3 protein is a plus-end tracking protein (+TIP) that dynamically regulates microtubule cytoskeletal dynamics by binding to the plus-end of microtubules. It promotes microtubule growth, stabilizes it at the centrosome, and regulates minus-end microtubule organization. EB3/MAPRE3 Protein, Human (His) is the recombinant human-derived EB3/MAPRE3 protein, expressed by E. coli , with N-His labeled tag. The total length of EB3/MAPRE3 Protein, Human (His) is 281 a.a., with molecular weight of ~34 kDa.

HY-P71102

	Tau-D/0N4R Protein, Human (133a.a, His) microtubule-Associated protein Tau; Neurofibrillary Tangle protein; Paired Helical Filament-Tau; PHF-Tau; MAPT; MAPTL; MTBT1; TAU	Human	E. coli
	Microtubule-associated protein tau is a microtubule-associated protein found in large numbers in neurons of the central nervous system (CNS). MAPT promotes microtubule assembly and stability and may be involved in the establishment and maintenance of neuronal polarity. Overexpression of MAPT is associated with a poor prognosis of prostate cancer. MAPT has been linked to neurological disorders such as Alzheimer's and Parkinson's disease. Tau-D/0N4R Protein, Human (133a.a, His) is the recombinant human-derived Tau-D/0N4R protein, expressed by E. coli , with C-6*His labeled tag. The total length of Tau-D/0N4R Protein, Human (133a.a, His) is 133 a.a., with molecular weight of ~16.0 kDa.

HY-P70909

	MAP1LC3B Protein, Human microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; MAP1A/MAP1B LC3 B; microtubule-associated protein 1 light cha	Human	E. coli
	MAP1LC3B is a key ubiquitin-like modifier essential for the formation of autophagosome vacuoles, which maintains cellular homeostasis. In mitophagy, it regulates mitochondrial number, suppresses reactive oxygen species and ensures energy efficiency. MAP1LC3B Protein, Human is the recombinant human-derived MAP1LC3B protein, expressed by E. coli , with tag free. The total length of MAP1LC3B Protein, Human is 125 a.a., with molecular weight of ~16.15 kDa.

HY-P701806

	MARK1 Protein, Human MARK1; Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c	Human	E. coli
	MARK1 is an important serine/threonine protein kinase that critically regulates cell polarity and microtubule dynamics. It phosphorylates microtubule-associated proteins (DCX, MAP2, MAP4, MAPT/TAU), causing their dissociation and disassembly. MARK1 Protein, Human is the recombinant human-derived MARK1 protein, expressed by E. coli , with tag free. The total length of MARK1 Protein, Human is 751 a.a., .

HY-P70916

	MAP1LC3A Protein, Human (His) microtubule-Associated proteins 1A/1B Light Chain 3A; Autophagy-Related protein LC3 A; Autophagy-Related Ubiquitin-Like Modifier LC3 A; MAP1 Light Chain 3-Like protein 1; MAP1A/MAP1B Light Chain 3 A; MAP1A/MAP1B LC3 A; microtubule-Associated protein 1 Light Cha	Human	E. coli
	MAP1LC3A is a key ubiquitin-like modifier essential for autophagosome vacuole formation, ensuring cellular homeostasis. As part of the GABARAP/GATE-16 subfamily, it plays a crucial role in late autophagosome maturation. MAP1LC3A Protein, Human (His) is the recombinant human-derived MAP1LC3A protein, expressed by E. coli , with C-6*His labeled tag. The total length of MAP1LC3A Protein, Human (His) is 121 a.a., with molecular weight of ~16.0 kDa.

HY-P701807

	MARK1 Protein, Human (His) MARK1; Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c	Human	E. coli
	MARK1 is an important serine/threonine protein kinase that critically regulates cell polarity and microtubule dynamics. It phosphorylates microtubule-associated proteins (DCX, MAP2, MAP4, MAPT/TAU), causing their dissociation and disassembly. MARK1 Protein, Human (His) is the recombinant human-derived MARK1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of MARK1 Protein, Human (His) is 751 a.a., .

HY-P70589

	Tau-F/MAPT Protein, Human DDPAC; FLJ31424; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPT; MGC138549; microtubule-associated protein tau; MSTD; MSTDMAPTL; MTBT1; MTBT1Neurofibrillary tangle protein; MTBT2; Neurofibrillary tangle protein; PHF-tau; PPND; Tau; TAUPaired helical filament-tau	Human	E. coli
	Microtubule-associated protein tau is a microtubule-associated protein found in large numbers in neurons of the central nervous system (CNS). MAPT promotes microtubule assembly and stability and may be involved in the establishment and maintenance of neuronal polarity. Overexpression of MAPT is associated with a poor prognosis of prostate cancer. MAPT has been linked to neurological disorders such as Alzheimer's and Parkinson's disease. Tau-F/MAPT Protein, Human is the recombinant human-derived Tau-F/MAPT protein, expressed by E. coli , with tag free. The total length of Tau-F/MAPT Protein, Human is 441 a.a., with molecular weight of ~60.0 kDa.

HY-P701678

	ERK1 Protein, Human (GST) MAPK3; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; microtubule-associated protein 2 kinase; p44-ERK1	Human	E. coli
	ERK1 protein is an important serine/threonine kinase in the MAP kinase pathway and cooperates with MAPK1/ERK2 to activate the MAPK/ERK cascade. Stimulated by KIT and KITLG/SCF, this pathway plays a key role in cell growth, adhesion, survival, and differentiation. ERK1 Protein, Human (GST) is the recombinant human-derived ERK1 protein, expressed by E. coli , with N-GST labeled tag. The total length of ERK1 Protein, Human (GST) is 378 a.a., .

Cat. No.	Product Name	Chemical Structure

HY-107116S

MAP4343-d4
MAP4343-d₄ is the deuterium labeled MAP4343. MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents[1][2][3].

Cat. No.	Product Name	Application	Reactivity

HY-P81053

MAP2 Antibody microtubule associated protein 2; MAP2A; MAP2B; MAP2C	WB, IF-Cell, IHC-P	Human, Mouse, Rat
MAP2 Antibody is an unconjugated, approximately 60 kDa, rabbit-derived, anti-MAP2 polyclonal antibody. MAP2 Antibody can be used for: WB, IF-Cell, IHC-P expriments in human, mouse, rat background without labeling.

HY-P80909

Tau Antibody MAPT; MAPTL; MTBT1; TAU; microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau	WB	Human, Mouse, Rat
Tau Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 79 kDa, targeting to Tau. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P80859

Phospho-Tau (Ser198) Antibody MAPT; MAPTL; MTBT1; TAU; microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau	WB, IP	Human
Phospho-Tau (Ser198) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 79 kDa, targeting to Phospho-Tau (Ser198). It can be used for WB,IP assays with tag free, in the background of Human.

HY-P80860

Phospho-Tau (Ser404) Antibody MAPT; MAPTL; MTBT1; TAU; microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau	WB	Human, Rat
Phospho-Tau (Ser404) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 79 kDa, targeting to Phospho-Tau (Ser404). It can be used for WB assays with tag free, in the background of Human, Rat.

HY-P80861

Phospho-Tau (Thr181) Antibody MAPT; MAPTL; MTBT1; TAU; microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau	WB, IP	Human
Phospho-Tau (Thr181) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 79 kDa, targeting to Phospho-Tau (Thr181). It can be used for WB,IP assays with tag free, in the background of Human.

HY-P81226

LC3 Antibody Autophagy related protein LC3 A; Autophagy related protein LC3 B; Autophagy related ubiquitin like modifier LC3 A; Autophagy related ubiquitin like modifier LC3 B; MAP1 light chain 3 like protein 1; MAP1 light chain 3 like protein 2; MAP1A/1B light chain 3 A; MAP1A/1B light chain 3 B; MAP1A/1BLC3; MAP1A/MAP1B LC3 A; MAP1A/MAP1B LC3 B; MAP1ALC3; MAP1BLC3; MAP1LC3A; MAP1LC3B; microtubule associated protein 1 light chain 3 alpha; microtubule associated protein 1 light chain 3 beta; microtubule associated proteins 1A/1B light chain 3; microtubule associated proteins 1A/1B light chain 3A; microtubule associated proteins 1A/1B light chain 3B; MLP3A_HUMAN.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Rat(predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Sheep, Goat)
LC3 Antibody is an unconjugated, approximately 14/16 kDa, rabbit-derived, anti-LC3 polyclonal antibody. LC3 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, rat, and predicted: mouse, chicken, dog, pig, cow, horse, sheep, goat background without labeling.

HY-P82405

MARK3 Antibody (YA2150) MARK3; CTAK1; EMK2; MAP/microtubule affinity-regulating kinase 3; C-TAK1; cTAK1; Cdc25C-associated protein kinase 1; ELKL motif kinase 2; EMK-2; protein kinase STK10; Ser/Thr protein kinase PAR-1; Par-1a; Serine/threonine-protein kinase p78	WB, ICC/IF, IP, FC	Mouse, Human

HY-P82250

RanBP9 Antibody (YA1995) B cell antigen receptor Ig beta associated protein 1; BPM 90; BPM L; BPM-L; BPM90; BPML; IBAP 1; Imp 9; Importin 9; Novel centrosomal protein RanBPM; RAN binding protein 9; Ran binding protein centrosomal; Ran Binding protein in the microtubule organizing center; Ran binding protein M; Ran BP9; Ran-binding protein 9; Ran-binding protein M; RANB9_HUMAN; RanBP 7; RANBP 9; RanBP7; RanBP9; RanBPM.	WB, ICC/IF	Human, Mouse, Rat

HY-P81156

phospho-ERK1 + 2 (Thr183/Tyr185) Antibody ERK1 + ERK2 (phospho Thr183/Tyr185); phospho-ERK1/MAPK-1/2(Thr183/Tyr185); ERK 1; ERK 2; ERK-2; ERK1; ERK2; ERT1; ERT2; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 2; Extracellular signal regulated kinase 2; Extracellular signal-regulated kinase 2; HS44KDAP; HUMKER1A; Insulin stimulated MAP2 kinase; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAP kinase isoform p44; MAPK 1; MAPK 2; MAPK1; MAPK2; MGC20180; microtubule associated protein 2 kinase; Mitogen activated protein kinase 1; Mitogen activated protein kinase 1; Mitogen activated protein kinase 2; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; MK01_MOUSE; p38; p40; p41; p41mapk; p42 MAPK; p42-MAPK; p42MAPK; p42MAPK; p44 ERK1; p44 MAPK; p44ERK1; p44ERK1; p44MAPK; p44MAPK; PRKM 1; PRKM 1; PRKM 2; PRKM 2; PRKM1; PRKM2; protein kinase mitogen activated 1; protein kinase mitogen activated 1; protein kinase mitogen activated 2; protein kinase mitogen activated 2; protein tyrosine kinas.	WB; ELISA; IHC-P; IHC-F; ICC; IF	Human, Mouse(predicted: Rat, Chicken, Dog, Cow, Horse, Rabbit, Guinea Pig)
phospho-ERK1 + 2 (Thr183/Tyr185) Antibody is an unconjugated, approximately 42/44 kDa, rabbit-derived, anti-phospho-ERK1 + 2 (Thr183/Tyr185) polyclonal antibody. phospho-ERK1 + 2 (Thr183/Tyr185) Antibody can be used for: WB, ELISA, IHC-P, IHC-F, ICC, IF expriments in human, mouse, and predicted: rat, chicken, dog, cow, horse, rabbit, guinea pig background without labeling.

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